MovDisordV3, Main, Exploration, bibRecord, 001156

Decision Making, Impulsivity, and Addictions: Do Parkinson's Disease Patients Jump to Conclusions?

Identifieur interne : 001156 ( Main/Exploration ); précédent : 001155; suivant : 001157

Decision Making, Impulsivity, and Addictions: Do Parkinson's Disease Patients Jump to Conclusions?

Auteurs : Atbin Djamshidian [Royaume-Uni] ; Sean S. O'Sullivan [Royaume-Uni] ; Yanosh Sanotsky [Ukraine] ; Stephen Sharman [Royaume-Uni] ; Yuriy Matviyenko [Ukraine] ; Thomas Foltynie [Royaume-Uni] ; Rosanna Michalczuk [Royaume-Uni] ; Iciar Aviles-Olmos [Royaume-Uni] ; Ludmyla Fedoryshyn [Ukraine] ; Karen M. Doherty [Royaume-Uni] ; Yuriy Filts [Ukraine] ; Marianna Selikhova [Royaume-Uni] ; Henrietta Bowden-Jones [Royaume-Uni] ; Eileen Joyce [Royaume-Uni] ; Andrew Lees (neurologue) [Royaume-Uni] ; Bruno B. Averbeck [Royaume-Uni, États-Unis]

Source :

Movement disorders [ 0885-3185 ] ; 2012.

RBID : Pascal:12-0340018

Descripteurs français

Pascal (Inist)
- Addiction, Maladie de Parkinson, Jeu pathologique, Abus de substance, Pathologie du système nerveux, Prise de décision, Substance toxicomanogène, Homme, Comportement.
Wicri :
- topic : Prise de décision, Homme.

English descriptors

KwdEn :
- Addiction, Aged, Antiparkinson Agents (therapeutic use), Behavior, Behavior, Addictive (etiology), Behavior, Addictive (psychology), Choice Behavior, Decision Making, Decision making, Drug of abuse, Educational Status, Female, Gambling, Human, Humans, Impulsive Behavior (etiology), Impulsive Behavior (psychology), Male, Memory, Short-Term, Middle Aged, Nervous system diseases, Neuropsychological Tests, Parkinson Disease (complications), Parkinson Disease (psychology), Parkinson disease, Pathological gambling, Psychomotor Performance, Reproducibility of Results, Substance abuse, Substance-Related Disorders (psychology).
MESH :
- chemical , therapeutic use : Antiparkinson Agents.
- complications : Parkinson Disease.
- etiology : Behavior, Addictive, Impulsive Behavior.
- psychology : Behavior, Addictive, Impulsive Behavior, Parkinson Disease, Substance-Related Disorders.
- Aged, Choice Behavior, Decision Making, Educational Status, Female, Gambling, Humans, Male, Memory, Short-Term, Middle Aged, Neuropsychological Tests, Psychomotor Performance, Reproducibility of Results.

Abstract

Links between impulsive-compulsive behaviors (ICBs) in treated Parkinson's disease (PD), behavioral addictions, and substance abuse have been postulated, but no direct comparisons have been carried out so far. We directly compared patients with PD with and without ICBs with illicit drug abusers, pathological gamblers, and age-matched healthy controls using the beads task, a test of reflection impulsivity, and a working memory task. We found that all patients with PD made more impulsive and irrational choices than the control group. PD patients who had an ICB showed similar behavior to illicit substance abusers, whereas patients without ICBs more closely resembled pathological gamblers. In contrast, we found no difference in working memory performance within the PD groups. However, PD patients without ICBs remembered distractors significantly less than all other patients during working memory tests. We were able to correctly classify 96% of the PD patients with respect to whether or not they had an ICB by analyzing three trials of the 80/20 loss condition of the beads task with a negative prediction value of 92.3%, and we propose that this task may prove to be a powerful screening tool to detect an ICB in PD. Our results also suggest that intact cortical processing and less distractibility in PD patients without ICBs may protect them from developing behavioral addictions.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3412901

Affiliations:

Le document en format XML

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<author><name sortKey="Fedoryshyn, Ludmyla" sort="Fedoryshyn, Ludmyla" uniqKey="Fedoryshyn L" first="Ludmyla" last="Fedoryshyn">Ludmyla Fedoryshyn</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurology, Lviv Regional Clinical Hospital</s1>
<s2>Lviv</s2>
<s3>UKR</s3>
<sZ>3 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Ukraine</country>
<wicri:noRegion>Lviv</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Doherty, Karen M" sort="Doherty, Karen M" uniqKey="Doherty K" first="Karen M." last="Doherty">Karen M. Doherty</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Molecular Neuroscience and Reta Lila Weston Institute for Neurological Studies, University of London</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>15 aut.</sZ>
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<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
<orgName type="university">Université de Londres</orgName>
</affiliation>
</author>
<author><name sortKey="Filts, Yuriy" sort="Filts, Yuriy" uniqKey="Filts Y" first="Yuriy" last="Filts">Yuriy Filts</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Lviv Regional Clinical Psychiatric Hospital</s1>
<s2>Lviv</s2>
<s3>UKR</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Ukraine</country>
<wicri:noRegion>Lviv Regional Clinical Psychiatric Hospital</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Selikhova, Marianna" sort="Selikhova, Marianna" uniqKey="Selikhova M" first="Marianna" last="Selikhova">Marianna Selikhova</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Molecular Neuroscience and Reta Lila Weston Institute for Neurological Studies, University of London</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
<orgName type="university">Université de Londres</orgName>
</affiliation>
</author>
<author><name sortKey="Bowden Jones, Henrietta" sort="Bowden Jones, Henrietta" uniqKey="Bowden Jones H" first="Henrietta" last="Bowden-Jones">Henrietta Bowden-Jones</name>
<affiliation wicri:level="3"><inist:fA14 i1="08"><s1>CNWL National Problem Gambling Clinic</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Joyce, Eileen" sort="Joyce, Eileen" uniqKey="Joyce E" first="Eileen" last="Joyce">Eileen Joyce</name>
<affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Department of Neuropsychiatry, Institute of Neurology, University College London</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>4 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J." last="Lees">Andrew Lees (neurologue)</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Molecular Neuroscience and Reta Lila Weston Institute for Neurological Studies, University of London</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
<orgName type="university">Université de Londres</orgName>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
<orgName>National Hospital for Neurology and Neurosurgery</orgName>
</affiliation>
</author>
<author><name sortKey="Averbeck, Bruno B" sort="Averbeck, Bruno B" uniqKey="Averbeck B" first="Bruno B." last="Averbeck">Bruno B. Averbeck</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health</s1>
<s2>Bethesda, Maryland</s2>
<s3>USA</s3>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Addiction</term>
<term>Aged</term>
<term>Antiparkinson Agents (therapeutic use)</term>
<term>Behavior</term>
<term>Behavior, Addictive (etiology)</term>
<term>Behavior, Addictive (psychology)</term>
<term>Choice Behavior</term>
<term>Decision Making</term>
<term>Decision making</term>
<term>Drug of abuse</term>
<term>Educational Status</term>
<term>Female</term>
<term>Gambling</term>
<term>Human</term>
<term>Humans</term>
<term>Impulsive Behavior (etiology)</term>
<term>Impulsive Behavior (psychology)</term>
<term>Male</term>
<term>Memory, Short-Term</term>
<term>Middle Aged</term>
<term>Nervous system diseases</term>
<term>Neuropsychological Tests</term>
<term>Parkinson Disease (complications)</term>
<term>Parkinson Disease (psychology)</term>
<term>Parkinson disease</term>
<term>Pathological gambling</term>
<term>Psychomotor Performance</term>
<term>Reproducibility of Results</term>
<term>Substance abuse</term>
<term>Substance-Related Disorders (psychology)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Behavior, Addictive</term>
<term>Impulsive Behavior</term>
</keywords>
<keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Behavior, Addictive</term>
<term>Impulsive Behavior</term>
<term>Parkinson Disease</term>
<term>Substance-Related Disorders</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Choice Behavior</term>
<term>Decision Making</term>
<term>Educational Status</term>
<term>Female</term>
<term>Gambling</term>
<term>Humans</term>
<term>Male</term>
<term>Memory, Short-Term</term>
<term>Middle Aged</term>
<term>Neuropsychological Tests</term>
<term>Psychomotor Performance</term>
<term>Reproducibility of Results</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Addiction</term>
<term>Maladie de Parkinson</term>
<term>Jeu pathologique</term>
<term>Abus de substance</term>
<term>Pathologie du   système nerveux</term>
<term>Prise de décision</term>
<term>Substance toxicomanogène</term>
<term>Homme</term>
<term>Comportement</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Prise de décision</term>
<term>Homme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Links between impulsive-compulsive behaviors (ICBs) in treated Parkinson's disease (PD), behavioral addictions, and substance abuse have been postulated, but no direct comparisons have been carried out so far. We directly compared patients with PD with and without ICBs with illicit drug abusers, pathological gamblers, and age-matched healthy controls using the beads task, a test of reflection impulsivity, and a working memory task. We found that all patients with PD made more impulsive and irrational choices than the control group. PD patients who had an ICB showed similar behavior to illicit substance abusers, whereas patients without ICBs more closely resembled pathological gamblers. In contrast, we found no difference in working memory performance within the PD groups. However, PD patients without ICBs remembered distractors significantly less than all other patients during working memory tests. We were able to correctly classify 96% of the PD patients with respect to whether or not they had an ICB by analyzing three trials of the 80/20 loss condition of the beads task with a negative prediction value of 92.3%, and we propose that this task may prove to be a powerful screening tool to detect an ICB in PD. Our results also suggest that intact cortical processing and less distractibility in PD patients without ICBs may protect them from developing behavioral addictions.</div>
</front>
</TEI>
<affiliations><list><country><li>Royaume-Uni</li>
<li>Ukraine</li>
<li>États-Unis</li>
</country>
<region><li>Angleterre</li>
<li>Grand Londres</li>
<li>Maryland</li>
</region>
<settlement><li>Londres</li>
</settlement>
<orgName><li>National Hospital for Neurology and Neurosurgery</li>
<li>Université de Londres</li>
</orgName>
</list>
<tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Djamshidian, Atbin" sort="Djamshidian, Atbin" uniqKey="Djamshidian A" first="Atbin" last="Djamshidian">Atbin Djamshidian</name>
</region>
<name sortKey="Averbeck, Bruno B" sort="Averbeck, Bruno B" uniqKey="Averbeck B" first="Bruno B." last="Averbeck">Bruno B. Averbeck</name>
<name sortKey="Aviles Olmos, Iciar" sort="Aviles Olmos, Iciar" uniqKey="Aviles Olmos I" first="Iciar" last="Aviles-Olmos">Iciar Aviles-Olmos</name>
<name sortKey="Bowden Jones, Henrietta" sort="Bowden Jones, Henrietta" uniqKey="Bowden Jones H" first="Henrietta" last="Bowden-Jones">Henrietta Bowden-Jones</name>
<name sortKey="Doherty, Karen M" sort="Doherty, Karen M" uniqKey="Doherty K" first="Karen M." last="Doherty">Karen M. Doherty</name>
<name sortKey="Foltynie, Thomas" sort="Foltynie, Thomas" uniqKey="Foltynie T" first="Thomas" last="Foltynie">Thomas Foltynie</name>
<name sortKey="Joyce, Eileen" sort="Joyce, Eileen" uniqKey="Joyce E" first="Eileen" last="Joyce">Eileen Joyce</name>
<name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J." last="Lees">Andrew Lees (neurologue)</name>
<name sortKey="Michalczuk, Rosanna" sort="Michalczuk, Rosanna" uniqKey="Michalczuk R" first="Rosanna" last="Michalczuk">Rosanna Michalczuk</name>
<name sortKey="O Sullivan, Sean S" sort="O Sullivan, Sean S" uniqKey="O Sullivan S" first="Sean S." last="O'Sullivan">Sean S. O'Sullivan</name>
<name sortKey="Selikhova, Marianna" sort="Selikhova, Marianna" uniqKey="Selikhova M" first="Marianna" last="Selikhova">Marianna Selikhova</name>
<name sortKey="Sharman, Stephen" sort="Sharman, Stephen" uniqKey="Sharman S" first="Stephen" last="Sharman">Stephen Sharman</name>
</country>
<country name="Ukraine"><noRegion><name sortKey="Sanotsky, Yanosh" sort="Sanotsky, Yanosh" uniqKey="Sanotsky Y" first="Yanosh" last="Sanotsky">Yanosh Sanotsky</name>
</noRegion>
<name sortKey="Fedoryshyn, Ludmyla" sort="Fedoryshyn, Ludmyla" uniqKey="Fedoryshyn L" first="Ludmyla" last="Fedoryshyn">Ludmyla Fedoryshyn</name>
<name sortKey="Filts, Yuriy" sort="Filts, Yuriy" uniqKey="Filts Y" first="Yuriy" last="Filts">Yuriy Filts</name>
<name sortKey="Matviyenko, Yuriy" sort="Matviyenko, Yuriy" uniqKey="Matviyenko Y" first="Yuriy" last="Matviyenko">Yuriy Matviyenko</name>
</country>
<country name="États-Unis"><region name="Maryland"><name sortKey="Averbeck, Bruno B" sort="Averbeck, Bruno B" uniqKey="Averbeck B" first="Bruno B." last="Averbeck">Bruno B. Averbeck</name>
</region>
</country>
</tree>
</affiliations>
</record>

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Movement Disorders (revue)

Decision Making, Impulsivity, and Addictions: Do Parkinson's Disease Patients Jump to Conclusions?

Decision Making, Impulsivity, and Addictions: Do Parkinson's Disease Patients Jump to Conclusions?

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	Movement Disorders (revue)
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